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Description

The derivatized AA-CoA or AdA-CoA is combined with CoA through ACSL4, and subsequently subjected to additional modifications by LPCAT3 to generate membrane phosphatidylethanolamine (AA-PE or AdA-PE) (Yu et al., 2023)

* [ 20-22] Alpha-glycerophosphocholine (Alpha-GPC), CDP-Choline (or Citicoline), and Uridine Monophosphate support the goals of augmenting choline pools and providing full pathway support

Independent phase-variable expression has also been observed in genes involved in haemoglobin-haptoglobin acquisition (Phillips et al., 2022) which is hypothesised to provide an adaptive response to fluctuations in haem-iron availability/source influenced by the stage or site of infection (Rao et al., 1999