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In cell-based assays, NCT-503 not only inhibited proliferation and induced apoptosis in multiple PHGDH-overexpressing cell lines but also blocked the incorporation of serine-derived carbon into nucleotides in both intracellular and extracellular contexts [9]

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however, it is affected by genetic and epigenetic alterations, transcriptional and post-transcriptional regulation, and post-translational modifications (Cavallini et al

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The effect of hydrogen peroxide and paraquat