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The improved survival rates observed with trastuzumab, even in real-world conditions, reinforce its critical role in treating HER2-positive breast cancer and support its sustained inclusion in SUS protocols

Livest Sci 112(12):822

Notably, a meta-analysis of the effects of CLA on inflammatory factors in adults indicates that CLA reduces levels of pro-inflammatory cytokines (e.g., TNF- and IL-6), while slightly increasing C-reactive protein (CRP) levels (99)

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A major limitation of the current literature is that the majority of evidence regarding the biological effects of OxPLs in tumors comes from in vitro systems and animal models, with only limited validation in human clinical samples