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Studies commonly focus on tendon and ligament injury models, muscle damage, wound healing, and gut irritation or ulcer models

Once-a-day dosing is common for drugs with minimal adverse effects related to peak concentrations that act on enzymes (eg, ACE inhibitors) or compete at receptors (eg, propranolol)

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reactions persisting beyond 48 hours or involving induration suggest sensitivity to the bacteriostatic water preservative (benzyl alcohol) rather than the peptide itself