PMID 11118286
FIGURE 3 8 Discussion Parkinsons disease is characterized by neuroinflammation caused by microglia, which exhibit both neurotoxic and neuroprotective effects depending on their activation state in the brains of individuals with PD
The method of Priority Applications (1) Applications Claiming Priority (4) Related Parent Applications (1) Publications (1) Family ID=35759146 Family Applications (4) Family Applications Before (3) Country Status (14) Cited By (1) Families Citing this family (9) Family Cites Families (32) 2004 2004-11-17 US US10/990,933 patent/US20060105972A1/en not_active Abandoned 2005 2005-11-16 KR KR1020077013535A patent/KR20070095900A/en not_active Ceased 2005-11-16 WO PCT/US2005/041458 patent/WO2006055597A1/en not_active Ceased 2005-11-16 BR BRPI0516814-7A patent/BRPI0516814A/en not_active IP Right Cessation 2005-11-16 DK DK05823154.9T patent/DK1824481T3/en active 2005-11-16 AU AU2005307885A patent/AU2005307885B2/en not_active Ceased 2005-11-16 CN CNA2005800393226A patent/CN101060840A/en active Pending 2005-11-16 EP EP05823154A patent/EP1824481B1/en not_active Expired - Lifetime 2005-11-16 JP JP2007543186A patent/JP2008520681A/en active Pending 2005-11-16 PL PL05823154T patent/PL1824481T3/en unknown 2005-11-16 MX MX2007005835A patent/MX2007005835A/en unknown 2005-11-16 EA EA200701017A patent/EA014076B1/en not_active IP Right Cessation 2005-11-16 CA CA2587616A patent/CA2587616C/en not_active Expired - Fee Related 2005-11-16 ES ES05823154T patent/ES2390228T3/en not_active Expired - Lifetime 2008 2008-07-30 US US12/182,354 patent/US8501700B2/en active Active 2013 2013-08-02 US US13/958,530 patent/US9144570B2/en not_active Expired - Lifetime 2015 2015-08-27 US US14/838,274 patent/US20160082029A1/en not_active Abandoned
coli cytoplasm, disulfide bonds don't form (reducing environment) Trx fusion + SHuffle strain enables cytoplasmic disulfide formation This can replace periplasmic expression (higher yields) or refolding (more reliable) Affinity purification: No intrinsic affinity tagtypically used as His6-Trx or Trx-Strep
Given that various chemical substances have been identified as neurotransmitters/neuromodulators in mammals, eliciting long-distance ionic responses that effectively mediate neurotransmission, identification of more systematic signaling molecules in the future would offer new insights into the complex systemic defense signaling in plants
