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doi: 10.1016/S0278-2391(97)90187-7 175 WinthropK

Acknowledgements We thank Xuewu Zhang for his comments on our paper

doi:10.1038/nrc2012 57

Understanding reduce melanin in skin is important to manage it effectively and reduce it

The increased oxidative load disrupts the bodys intrinsic antioxidant defense systems, such as manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx), leading to lipid peroxidation, DNA damage, and activation of pro-apoptotic pathways, such as p53 and BAX 5,7