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Ciura K, McBurney M, Nguyen B, Pham M, Rebueno N, Fuller CD, Guha-Thakurta N, Rosenthal DI

It can increase IDO levels through the STAT3 pathway, thereby enhancing the significant immunosuppressive function of MDSCs [482, 483]

Daunorubicin was administered as a single intraperitoneal injection on three consecutive days

This process is mediated by the enzyme glutathione S-transferase, which attaches glutathione to toxic substances, making them more water-soluble and thus easier to excrete

In order to expand the idea to the other solid tumors, it is also suggested to evaluate the miR-223/FOXO3a axis in other cancers and broaden the idea