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Furthermore, a recent study reported that ranolrazole could attenuate IM by inhibiting GPX4 expression to enhance ferroptosis (Fig

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If ETC function is impaired, the TCA cycle can continue to generate metabolites by reductive mechanisms, including using pyruvate carboxylase to generate oxaloacetate from pyruvate for aspartate production, and glutamine-dependent reductive carboxylation for citrate synthesis (22, 23)

Physiological symptoms include metabolic acidosis, neurological defects, and increased susceptibility to pathogenic infections