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The response of OTA-orally administered mice also showed marked increases in these enzymes and KIM-1

Single-herb interventions have been reported to modulate key metabolic enzymes and signalling pathways involved in lactate production and lactacidification [67, 91], whereas classical compound formulations exert synergistic actions that contribute to the holistic remodelling of the renal microenvironment [96, 97]

This focused subset yielded a highly significant enrichment of metabolic and mitochondrial programs, including metabolism, aerobic respiration and respiratory electron transport and additional pathways related to mitochondrial protein turnover and Complex IV assembly (Supplementary Figure S5)

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