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Interested in gut peptides, in 1980 Lund found a gene for the glucagon precursor in Goodman's library (Lund, Goodman, Dee, Habenerr)

STEP 2, conducted in adults with type 2 diabetes, showed 9.6% weight loss with Semaglutide 2.4 mg (Davies et al., Lancet 2021

Metformin functions by activating AMPK, which inhibits hepatic lipid synthesis, enhances hepatic fatty acid oxidation, facilitates the phosphorylation of target substrates, and supports mitochondrial function and adipose tissue integrity

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