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Weight loss is very common among patients with pancreatic cancer, both at the time of diagnosis, as well as during the course of the disease

However, species differences limit direct extrapolation

Exp Neurol 274:7279

The formation of is an irreversible process catalyzed by pseudouridine synthases (PUS) via two distinct pathways: a protein-only mechanism mediated by PUS enzymes and an RNA-dependent mechanism involving box H/ACA ncRNAs and the Cbf5/dyskerin complex [103]