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Laboratory evidence indicates it is incredibly effective at reducing white adipose tissue

The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

Although the product is not third-party tested, our experts were very impressed by the level of testing and quality control that Now conducts

Researchers study NNMT inhibition in the context of cellular NAD metabolism, methylation pathways, and metabolic regulation

Epigenetic drift and altered gene expression NAD+ shortage drives epigenetic changes by reducing sirtuin activity