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Conversely, we have also demonstrated that exacerbated activation of the BH4 pathway is pathogenic, causing mitochondrial dysfunction, increasing the aggressiveness of the immune system, inducing pain hypersensitivity, and the progression of symptoms of chronic diseases, including chronic pain, asthma, multiple sclerosis, ulcerative colitis, rheumatoid arthritis, cognitive impairment, and others [83,84,85,86,87]

Supplementary Table 3 Performance metrics of nine machine learning models for prostate cancer classification

Effects of endogenous ascorbate on oxidation, oxygenation, and tox-icokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig

Estimation of catalase

More rigorous pre-clinical and clinical research studies need to be conducted before Thymoquinone/Nigella sativa can be routinely used as an effective complementary or alternative treatment