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Maternal RPM supplementation, utilizing two different products available in the market (Smartamine M or MetaSmart) during the last 21 days of gestation, promoted a reduction in plasma positive acute-phase proteins, accompanied by a decrease in plasma IL-6 after calving, indicating a reduction in proinflammatory responses (Osorio et al., 2014b)

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FIGURE 6 The COVID-19 pandemic, caused by the 2019 novel coronavirus, is spreading globally

Gut microbiota dysbiosis can also induce an inflammatory response and affect the metabolism of bile acids (BAs), short-chain fatty acids (SCFAs), trimethylamine-N-oxide (TMAO) and other bioactive molecules, resulting in systemic inflammation and endothelial dysfunction

In CKD patients, reduced corin expression in the kidney and decreased urinary soluble corin levels have been reported [58] whereas its overexpression in the UUO model attenuated fibrosis progression [59]