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Das Ergebnis der Recherche ist ernchternd

Current review article on wound healing

High activity of TGF- [187, 188], histone deacetylase 8 (HDAC8) [189], p21-activated kinase 4 (PAK4) [190, 191], protein phosphatase 2 A (PP2A) [192], cyclin-dependent kinase 4/6 (CDK4/6) [160, 193], orphan GPR182 [194], and WNT/-catenin [195,196,197], as well as loss of phosphatase and tensin homolog (PTEN) [198,199,200], hamper CD8 + T-cell infiltration and promote their exclusion

For the rotarod assay, forelimb grip strength test, and neurophysiology CMAP recordings, there was no significant difference throughout disease progression over the course of 47 days between treated and untreated groups (Fig