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Similar content being viewed by others Introduction Melasma affects photoexposed areas, especially in women of reproductive age, but no curative treatment is available, significantly impacting the quality of life, including low self-esteem that leads to social contingencies, anxiety, and depressive symptoms [1,2,3]

The SI unit is kilogram per cubic metre (kg/m 3 ), though it is commonly reported as grams per liter (g/L)

Unlike injections, topicals provide a more targeted application, as they can be used directly on the skin and scalp surfaces

To overcome these limitations, a shift toward personalized exercise prescriptions, tailored to individual health status, preferences, and treatment stage, is increasingly advocated

Hendriksen et al., 2015)