Conversely, at higher concentrations, it tends to accumulate within the nonpolar chains of the phospholipid bilayer ( In vivo studies on rats showed poor absorption of orally administered curcumin, with more than 90% excreted in feces within 72 h ( Plasma concentrations remained minimal, even at high doses, with most curcumin localized in the small intestine and little reaching systemic circulation, resulting in a bioavailability of approximately 1% ( 8.2 Metabolism and elimination of curcumin Curcumins bioavailability in humans is mostly limited by poor intestinal absorption, rapid hepatic metabolism, and rapid systemic elimination, even at high doses of 12 g/day ( Figure 4
It contains, for example, vitamins from the group: C, Curcuma, Green tea leaf extract, organic ginger root concentrate, olive tree extract Ginkgo Biloba- extract from ginkgo biloba, which inhibits platelet aggregation and thus increases its flow in the body
Rosell R, Jain A, Codony-Servat J, Jantus-Lewintre E, Morrison B, Ginesta JB, et al
185 WadaK.HiratakeJ.IrieM.OkadaT.YamadaC.KumagaiH.et al (2008)
Adult patients with cirrhosis were divided into 2 groups: Group 1 included patients with a history of SBP who were initiated on ciprofloxacin or norfloxacin, or Bactrim, i.e., patients on secondary prophylaxis for SBP