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Thus, studies conducted on animals have demonstrated that inhibition of the endogenous methylation demand by creatine supplementation can reduce Hcy levels, but these results have not been reproduced in human subjects

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In osteosarcoma (HOS and 143B) cells, UA promotes autophagic degradation of ferritin, leading to iron overload, lipid peroxidation, and ferroptosis, thereby increasing cisplatin's effectiveness [1049]

Glucagon-like peptide-1 (GLP-1) is a multifunctional polypeptide that activates GLP-1 receptor (GLP-1R), playing a crucial role in neuroprotection [45]

In addition, there is limited opportunity to perform experiments on humans and as such, human microbiome studies are defined primarily by fecal samples which mainly represent only a small portion of the large intestine microbial community