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The primary antibodies used were as follows: anti-MAPL (16133-1-AP, 1:1 000, Proteintech), anti-SENP5 (ab58420, 1:500, Abcam), anti-SUMO1 (67559-1-Ig, 1:1 000, Proteintech), anti-cleaved caspase-3 (AF7022, 1:500, Affinity Biosciences), anti-Bax (#2772, 1:1 000, Cell Signalling Technology), anti-Bcl-2 (1:1 000, ab196495, Abcam), anti-Drp1 (#8570, 1:1 000 (IB) or 1:100 (IP), Cell Signalling Technology), anti-VDAC1 (ab15895, 1:3 000, Abcam) and anti--actin (TDY051, 1:10 000, TDY Biotech)

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Since the key is used for both encryption and decryption, it is vital for us to store it safely to prevent unauthorized access to it

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