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Cell 120: 99110 PujolCarrion N, Belli G, Herrero E, Nogues A, de la TorreRuiz MA (2006) Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae

omega 3 & 6 ALA DHA & EPA), and lipid (fatty acid) peroxidation (damage) of the sperm membrane is the key mechanism of this ROS-induced sperm damage, leading to infertility

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

& Kanaar, R

doi: 10.1016/j.arr.2023.102181 140