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Specifically, NAD + serves as a cofactor for oxidoreductases involved in (1) glycolysis (glyceraldehyde phosphate dehydrogenase, GAPDH), (2) oxidative decarboxylation of pyruvate to acetyl-CoA (pyruvate dehydrogenase), (3) tricarboxylic acid cycle (-ketoglutarate, isocitrate and malate dehydrogenases), (4) -oxidation of fatty acid (3-hydroxyacyl-CoA dehydrogenase) and (5) alcohol metabolism (alcohol and aldehyde dehydrogenases), thereby harvesting energy in the form of ATP from fuel substrates, such as glucose, amino acids and fatty acids (Fig

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BCSCs are also sensitive to combined targeting of the GSH and TRX pathways (Fig

Wang, S., Wu, J., Shen, H