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doi: 10.1080/1040841X.2025.2510256 199 ZhiluX.XiangqianD.KeliY.CarolineC.JingwanZ.YuL.et al

Even with the application of model-informed precision dosing, especially given the fact that busulfan shows considerable between-day variability, there will be a proportion of patients who will fail to achieve optimal exposure with dose 1, thus necessitating repeat blood collections and dose modifications

DOI: 10.1111/j.1523-5378.2011.00830.x

Researchers prevent this by immediately deproteinizing samples with acidic solutions such as metaphosphoric acid (MPA) or perchloric acid (PCA) and processing all materials on ice