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Mice model carrying a selective ablation of AR in myofibers (AR skm/y mice) exhibits a decrease of glucose uptake and glycolytic activity, thus contributing to early-onset type 2 diabetes

Indeed, it has been demonstrated that acetylation plays a key role in the control of CACT function that, together with the long-chain acyl-CoA dehydrogenase, contributes to -oxidation regulation

References Lindblad, B., Lindblad, B

The cobalamin type is caused by congenital defects in the synthesis, activation or transport of cobalamin (the allosteric coenzyme), which affect the function of MCM by disrupting the synthesis of its coenzyme deoxyadenosylcobalamin

Cell Syst