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Risk versus risk: a review of benzodiazepine reduction in older adults

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However, activation of LXRs could be a double-edged sword, as LXRs are highly expressed in haematopoietic stem cells and myeloid progenitor cells, in which they decrease the proliferative responses to IL-3 and GM-CSF (Murphy et al., 2011)

This reflects the inherent plasticity of the metabolic system, which can also act as a driver of disease progression (Fig

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