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Two papers also included healthy controls (Holmay et al

Despite their relatively short disease duration and low disability score, our RRMS cohort displayed cognitive impairment, evidenced by poorer visuospatial, fluency and attention scores, as well as lower overall performance scores on the ARCS than the HCs

the invention provides improved lipid formulations comprising a cationic lipid of formula I, a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula I is the lipid is a racemic mixture

This escalation approach is standard across GLP-1 class compounds and serves to improve gastrointestinal tolerability

Patients should be advised that tirzepatide is not a controlled substance and does not carry abuse potential like stimulant medications