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The renal or extrarenal expression of 1--hydroxylase (CYP27B1) enzymatic action converts 25(OH)VD 3 to an active metabolite 1,25-dihydroxy vitamin D 3 (1,25(OH) 2 VD 3) 13

Overall, the limited number of high-quality, controlled trials examining tart cherry supplementation in surgical populations underscores the need for future randomized studies to determine optimal dosing, timing, and clinical impact within perioperative recovery frameworks

Arch Biochem Biophys 595:6163 Kannan R, Chakrabarti R, Tang D, Kim KJ, Kaplowitz N (2000) GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC

Granulathiazole A reduces -synuclein accumulation through NRF2/HO-1 activation (126) and betulinic acid improves behavioral outcomes by reducing ROS levels (127)

The reduction of intracellular iron may disturb activity and homeostasis between osteoclasts and osteoblasts, leading to dysregulation of bone balance and ultimately bone loss