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Additionally, a 1% (w/w) dietary intake of vitamin C has been shown to reduce cataractogenesis in streptozotocin (STZ)-induced diabetic rat models by decreasing -crystallin leakage (48,49) and relieving oxidative stress by increasing GSH peroxidase (GSH-Px) activity and reducing peroxidation levels (50)

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Excessive production of ROS not only directly damages cellular membranes, proteins, and DNA, but also activates inflammatory signaling pathways such as NF-B, thereby promoting the release of pro-inflammatory cytokines including TNF-, IL-1, and IL-6