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doi: 10.1038/s41418-022-00943-y 20 WangMAttardiLD

Clinical review 91: female sex hormones and cardiovascular disease in women

TB-500 operates systemically as a **cytoskeleton remodeler**: its primary function is G-actin monomer sequestration (active N-terminal Ac-Ser-Asp-Lys-Pro), its cleaved AcSDKP sequence is an **autonomous angiogenic factor**, it upregulates laminin-5 and matrix metalloproteinases (MMPs), and mobilizes mesenchymal progenitor cells