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Since both drugs influence gastrointestinal function, starting with lower doses and gradual titration is generally advised

(Based on [32] ) The mice with HT29 wild type metastatic disease, mostly non angiogenic, did not responded well to treatment with the VEGFA inhibitory antibody B20-4.1.1, however this antibody was effective in significantly reducing the neoplastic bulk in mice injected with ARP2/3 negative HT29 cells