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A42 oligomers, which are associated with early AD, have been found to hyperactivate AMPK, leading to synaptic loss via Mitochondrial Fission Factor (MFF) -dependent mitochondrial fission and ULK2-dependent mitophagy (Lee et al

Therapeutic strategies are exploring GPx4 mimetics to inhibit ferroptosis, potentially offering new treatments for conditions like stroke or neurodegeneration