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Luteolin has exerted its anti-inflammatory effect by inhibiting pro-inflammatory mediators such as cyclooxygenase-2 (COX-2), nitric oxide (NO), TNF-, IL-, IL-6, IL-8, IL-31, and IL-33 in several in vitro models of AD [42], PD [43, 44], MS [45], and in vivo models of AD [27, 46]

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