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Structure 20 , 604617 (2012)

One of the major needs related to the use of phytotherapeutics in AD is indeed the reduction of severe side effects of current drugs while maintaining their medicinal potentials and efficacy (Varshney and Siddique, 2021)

Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels