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IC 50 values and the percentage of viable cells were calculated using SPSS version 25

Rang and Dales Pharmacology

Environmental Circadian Disruption Elevates the IL-6 Response to Lipopolysaccharide in Blood

Mechanism of toxicity Toxicity is known to occur through lead-induced oxidative stress [5]

found that Lipoxin A4 could increase GPX4 levels by activating the ESR2/LPAR3/Nrf2 axis, inhibit FLS ferroptosis, thereby reducing synovial inflammation, alleviating cartilage degeneration, and mitigating pain and pathological progression in knee OA (Hu et al., 2024)