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A small randomized pilot trial reported a benefit as an add-on in Parkinsons, but the broader epidemiology is mixed and some diabetic cohorts link long-term high-dose use to higher Parkinsons risk

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An increase in daily niacin intake of 6.2 mg was associated with about a 40% decrease in cases of cancers of the mouth and throat, while a 5.2 mg increase in daily niacin intake was associated with a similar decrease in cases of esophageal cancer (58, 59)