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& Stein, D

doi: 10.1002/cphy.c170050, 134

In Nlgn2 R215H mutant mice, inhibitory synaptic transmission is significantly reduced in the prefrontal cortex, accompanied by decreased levels of the GABAA receptor 2 subunit and vesicular transporters

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Some conditions that are especially benefited by increasing NAD+ levels are: See list of conditions benefitted by NAD+ Substance Abuse Depression Addiction Chronic Pain Sleep Disorders Brain Injury Autism Mitochondrial Disease Lyme Disease Chronic Fatigue Improving Physical Performance in Athletics Anxiety Neurodegeneration You will notice that many of the conditions mentioned involve suboptimal functioning of the brain and nervous system