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The trial demonstrated a statistically significant improvement in OS and PFS for patients randomized to pemetrexed in combination with pembrolizumab and platinum chemotherapy compared with placebo, pemetrexed, and platinum chemotherapy (see Table 10 and Figure 1)

Hutchinson AJ, Chou CL, Israel DD, Xu W, Regan JW (2009) Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF