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In all phase 3 studies, tirzepatide was initiated at 2.5 mg sc once weekly and escalated by 2.5-mg increments every 4 weeks until the target dose of 5, 10 or 15 mg sc per week was reached [8,9,10,11,12]

We previously found that fusion of a peptide or a single-chain variable fragment to the C-terminal end of albumin reduced FcRn binding up to 2-fold, and to a greater extent than when fused to the N-terminal end 12