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Furthermore, a notable rise in the expression levels of genes associated with autophagy, as well as a higher quantity of autophagic vacuoles and lysosomes, has been detected in degenerated intervertebral discs and the annulus fibrosus (181, 182)

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The randomized, double-blind, placebo-controlled trial, published in the 2016 International Journal of Allergy, Asthma, Immunology also demonstrated that Vitamin A therapy reduced symptoms and improved outcomes in this population

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