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Thron, S

At the same time, the public evidence base has leaned heavily on animal studies, mechanism papers, small human reports, and anecdotal recovery stories

doi: 10.1146/annurev-pharmtox-011112-140320 31 RazaviSMSoltanMSAbbasianKKaramiANazifiS

In its natural state, quercetin is not highly water-soluble, and the human digestive tract struggles to absorb it

It is less appropriate as a first step for very mild acne, for skin that is actively irritated, or for certain medical situations that a provider screens for