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These findings suggest that artificial selection in domestic dogs may have inadvertently reduced antioxidant capacity and that small dogs may survive longer despite experiencing increased oxidative damage

Concomitantly, systemic oxidative stress arising during liver damage can affect extrahepatic organs

An early study reported a similarity between FSP1 and apoptosis-inducing factor mitochondria-associated 2, but this finding was disproved in a subsequent study [43]

Glutathione S-transferases (GSTs) catalyze the conjugation of GSH to a broad range of electrophilic compounds, including endogenous signaling molecules, reactive aldehydes such as 4-hydroxynonenal (4-HNE), and heavy metals 13,14

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