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In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau

In WT mice, both Cagrilintide and sCT significantly increased cFos expression in these hindbrain nuclei compared to vehicles, indicating activation of satiety-related pathways

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Furthermore, participants receiving Cagrilintide 4.5 mg achieved greater weight loss than those on liraglutide 3.0 mg demonstrated by a 10.8% vs

V., et al