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Notably, intravenous administration of 0.5 mg/kg PBGD mRNA formulated by lipid nanoparticles into Cynomolgus macaque achieved 40% and 90% increases in the activity and expression level of PBGD, respectively, in comparison to the phosphate buffered solution (PBS) treated animals [154]

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Mutational signatures play a significant role in assessing tumor prognosis and predicting the efficacy of immunotherapy

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