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It induces purified mitochondria to release the apoptogenic proteins cytochrome c and caspase-9

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Among them, oxidative stress is considered the cornerstone where cyclophosphamide elicits massive generation of ROS coupled with downregulating activities of antioxidant enzymes alongside Nrf2 pathway

HIF stabilisers are emerging as an innovative therapeutic strategy for the treatment of IBD ( In vivo studies with 4-mercapto butyrate confirmed this pattern for systemic HIF stabilisation in mice (Ornelas et al., 2023)

My hope is that a team-based approach with patient-centered care will become the new normal