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www.nejm.org/doi/full/10.1056/NEJMoa2032183.

It lies adjacent to key structures such as the pituitary gland, optic chiasm, and ventricular system, which circulates cerebrospinal fluid (CSF)

(2023, February 23)

This can happen during falls, car accidents, or sports impacts

147 The paracellular pathway is the principal route blocked by the tight junctions of cell gaps, restricting ions, polar solutes, and most macromolecules