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That is the pathway by which GSTP-silencing initially inhibits mitochondrial function and subsequently facilitates ROS generation to induce oxidative stress

Costa JR, Xavier M, Amado IR, Gonalves C, Castro PM, Tonon RV, Cabral LMC, Pastrana L, Pintado ME (2021) Polymeric nanoparticles as oral delivery systems for a grape pomace extract towards the improvement of biological activities

Redox Biol 75:103256 Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S et al (2013) Wilsons disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

However, in a recent study on the inhibition of Hepa1-6 cell proliferation induced by oxidative stress, we found that increased expression of GPX6 protein may play a role in inhibiting oxidative stress (Tan et al., 2022)

2F) which shows the similar result of Raji cells