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PDOs have been instrumental in understanding the genetic and epigenetic landscape of resistance, providing personalized models for testing drug combinations and identifying patient-specific resistance patterns [152, 153]

Each treatment replicated five times, and a total of 20 pots were randomly arranged

Subsequently, the extracted RNA was reverse transcribed into cDNA using a thermal cycler with programmed temperature steps

Adaptations within the TME create a competition for nutrients required by myeloma cells with their neighboring non-tumor cells

AGXT2 also may degrade asymmetric dimethylarginine, an endogenous inhibitor of NOS