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Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex

doi: 10.3389/fimmu.2025.1700004 Received 05 September 2025 Revised 11 November 2025 Accepted 18 November 2025 Published 05 December 2025 Corrected 19 December 2025 Volume 16 - 2025 Edited by Peng Wang, Coriell Institute For Medical Research, United States Reviewed by Wentong Li, Shandong Second Medical University, China Yang Yang, First Affiliated Hospital of Zhengzhou University, China Updates Copyright 2025 Luo, Long, Wu and Zeng

As a first-generation ferroptosis inhibitor, its core mechanism involves direct interception of lipid radicals to terminate peroxidation chain reactions: its arylamine group (-NH-) donates hydrogen atoms (H) to reduce lipid peroxyl radicals (LOO LOOH), a mechanism analogous to vitamin E but with superior ferroptosis-inhibitory efficacy (237)

Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia