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From a multi-omics perspective, this local endocrine state can be captured at multiple levels, including (i) follicular-fluid steroidomics (e.g., estrogen/androgen balance as a proxy for aromatization capacity), (ii) granulosa/cumulus transcriptomic and proteomic signatures encoding steroidogenic and steroid-converting machinery, and (iii) metabolomic correlates of hormone-linked mitochondrial and redox programs associated with maturation competence [249, 252]

Today we know that the extracellular matrix (ECM) is extremely important for skin structure, i.e

doi: 10.1007/s00011-010-0214-4

Schmidt-Mende K

van Leeuwen PT, van der Peet JM, Bikker FJ, Hoogenkamp MA, Oliveira Paiva AM, Kostidis S et al