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GLP-1 use is safe and effective with many pre-existing conditions with the exception of the following: Currently pregnant Currently breastfeeding Currently being treated for cancer Active eating disorder Active gallbladder disease Active substance abuse or dependency Type 1 diabetes Bariatric surgery (within the past 18 months) Pancreatitis within the past 6 months, or a history of pancreatiitis caused by taking a GLP-1 Personal or family history of medullary thyroid cancer or MEN syndrome Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

PD patients on pump-based continuous delivery of dopaminergic medication will benefit from extending the pump running time through the night

In reality, metabolism is far more complex

Adipose tissue as a buffer for daily lipid flux

Vitamin B12 is naturally present almost exclusively in animal-derived foods, making vegans and strict vegetarians particularly vulnerable unless they consume fortified foods or supplements