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333,334 Furthermore, specific expression of CYP2J2 in cardiomyocytes could also improve diabetic cardiomyopathy, while inhibiting sEH renders an additional protective effect against diabetic nephropathy by activating the PI3K-AKT-NOS3 and AMPK signaling cascades

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Table 3: Laboratory Abnormalities Worsened from Baseline in 20% of Patients in KEYNOTE-189 *Each test incidence is based on the number of patients who had both baseline and at least one on-study laboratory measurement available: pemetrexed/pembrolizumab/platinum chemotherapy (range: 381 to 401 patients) and placebo/pemetrexed/platinum chemotherapy (range: 184 to 197 patients)

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